Bone Marrow Transplant for Thalassemia in India
Thalassemias are form of inherited autosomal recessive blood disorders that originated in the Mediterranean region in India. Thalassemias cause the body to make fewer healthy red blood cells and less hemoglobin than normal. People who have Thalassemias can have mild or severe anaemia. Anaemia is caused by a lower than normal number of red blood cells.
Reason for Thallesemia
Normal haemoglobin also called hemoglobin A has four protein chain two alpha globin and two beta globin. The two major types of Thalassemia alpha and beta are named after defects in these protein chains. Four genes (two from each parent) are needed to make enough alpha globin protein chains.
Alpha Thalassemia trait occurs if one or two of the four genes are missing. If more than two genes are missing, moderate to severe anemia occurs. Beta Thalassemia occurs if one or both genes are altered. The severity of beta Thalassemia depends on how much one or both genes are affected. Both alpha and beta Thalassemia includes the following two forms: